TU Delft

Biofilm control strategies based on the enzymatic disruption of the EPS matrix – a modelling study

Joao B. Xavier (1,2,*), Cristian Picioreanu (2), Suriani Abdul Rani (1), Mark C.M. van Loosdrecht (2), Philip S. Stewart (1)

(1) Center for Biofilm Engineering and Department of Chemical and Biological Engineering, Montana State University-Bozeman, Bozeman, Montana, 59717-3980, USA
Tel: +1-406-9940-2890, Fax: +1-406-6098

(2) Department of Biotechnology, Delft University of Technology
Julianalaan 67, 2628 BC Delft, The Netherlands.
Tel: +31-(0)15-2781551, Fax: +31-(0)15-2782355
*Corresponding author. E-mail: J.Xavier@tnw.tudelft.nl

This web page contains support material for our paper entitled "Biofilm control strategies based on the enzymatic disruption of the EPS matrix – a modelling study". The paper is published in Microbiology SGM 151:3817-3832.

This page contains video files of the simulations presented in the paper.

The cover of Microbiology issue containing this article reproduces a series of images from our article. See http://mic.sgmjournals.org/content/vol151/issue12/cover.shtml


3D simulations

The following is a summary of the simulations presented in the article. In addition, all simulations carried ouy for this study are also available at the Complete Simulations downloads page.

  Animation description   From figure in article Download
Transmission mode scanning laser microscopy of S. epidermidis biofilms grown for 24 h in glass capillary tube. The animation shows the deformation of a biofilm cluster and its consequent detachment after changing the influent medium to a solution with 0.1 g/L of NaOH Figure 1 JX-Sepi-NaOH
Results from the simulation U1 of undisturbed biofilm growth for 100 days (2400 h) Figure 3 control_rd_1.0E-4_
Results for simulation of the action of a DPA on a 60 days old biofilm. Simulation were carried out at Thiele modulus of 3.6, Damköhler number of 0.71 and YEPS* of 1. Figure 5 CaseStudy2_

Additional links

See also the following material:

Monospecies 2D model A java applet with an interactive simulation of the program used in the paper
Electronic Poster Electronic verision of a poster introducing the framework. Contains additional animations of simulations carried out using the framework
More simulations Carried out for the paper "A modelling study of the activity and structure of biofilms in biological reactors"

2005 - Biofilm modelling group at the TU Delft